The Uab Research Foundation

Other

Southern Research Institute

Vijayakrishna K Gadi

Eric J Sorscher

William B Parker

Leonard L Bennett, Jr

William Waud

Louise T Chow

Thomas R Broker

Nianxiang Zou

The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.

Recombinant bacterial cells for delivery of PNP to tumor cells

A replicon for delivery of a transgene for episomal gene expression in a mammalian host cell includes a transgene having an open reading frame or other nucleic acid sequence for transcription into RNA and under the transcriptional control of a first surrogate promoter and a first gene sequence expressing a papillomavirus replication initiator protein E1 tinder tile control of a second surrogate promoter. The replicon also includes second gene sequence expressing the papillomavirus replication origin binding protein E2 under the control of a third surrogate promoter, wherein tile transgene, the first and the second sequences are incorporated within at least one plasmid and less than three plasmids.

Human papillomavirus vectors for the episomal transduction of host cells and method of making same

Growing community of inventors

Birmingham, AL, United States of America

Vijayakrishna K Gadi