H.b. Fuller Company

Optmed, Inc.

E-therapeutics Plc

Vijaya Bhasker Gondi

John Gregory Reid

Steven James Collier

Nicholas John Holman

James Thomson Loch, Iii

Process for the production of methylidene malonates and cyanoacrylates employing in-situ formed iminium salts derived from acid halides and/or acid anhydrides and N,N,N',N&#x2032;-tetra hydrocarbyl diaminoalkanes, the acid halides and/or acid anhydrides being present in a molar excess relative to the diaminoalkanes, as co-reactants with select malonic acid esters and cyanoacetates, respectively.

1,1-disubstituted ethylene process

Improved iminium based processes for the production of cyanoacrylates and methylidene malonates wherein the improvement pertains to the presence of acid chlorides and/or acid anhydrides in the reaction mix.

There is described a method of preparing a compound of formula I, and optical isomers thereof; in which Ris hydrogen or a protecting group; said method comprising oxidizing verbenone and optical isomers thereof. 

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Burlington, MA, United States of America

Vijaya Bhasker Gondi