Mayo Foundation for Medical Education and Research

University of Pittsburgh

Nanosyn, Inc.

Vijay Prem Singh

Kevin Lloyd Greenman

Sampath-Kumar Anandan

Zeeshan Kamal

Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.

Compounds for the reducing lipotoxic damage

Materials and methods for producing localized hypothermia in a patient (e.g., for treatment of acute pancreatitis and pancreatic cancer).

Gastroduodenal balloon tubes and methods for use in localized hypothermia

The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor. It is based, at least in part, on the discoveries that lipotoxicity contributes to inflammation, multisystem organ failure, necrotic pancreatic acinar cell death and in acute pancreatitis, and that inhibition of lipolysis was able to reduce indices associated with these conditions. Accordingly, in various embodiments, the present invention provides for methods and compositions for limiting lipotoxicity and thereby reducing the likelihood of poor outcomes associated with acute pancreatitis and other severe systemic conditions, especially in obese individuals.

Lipase inhibitors for the treatment of pancreatitis and organ failure

Materials and Methods for producing localized hypothermia in a patient for treatment of a weight disorder (e.g., obesity).

Growing community of inventors

Pittsburgh, PA, United States of America

Vijay Prem Singh