Council of Scientific and Industrial Research

Other

Vijay Kumar Sethi

Subhash Chandra Taneja

Ghulam Nabi Qazi

Samar Singh Andotra

Brijesh Kumar

Ajit Kumar Saxena

Vijeshwar Verma

Surrinder Koul

Suresh Chandra

Sanghapal Damodhar Sawant

Shashank Kumar Singh

Kanaya Lal Dhar

Randhir S Kapil

Pankaj Gupta

Ashok Kumar Shahi

Prabhu Dutt

Satya Narayan Sharma

Abid Hussain Banday

Monika Verma

Sanotosh Kumar Bakshi

Maharaj Krishan Koul

Ghularn Nabi Qazi

Abid Zaffar Hashmi

Mahabalarao Sampath Kumar Halmuthur

Mushtaq Ahmad Aga

Naveed Ahmed Qazi

Shubash Chandra Taneja

Mahendhar Reddy Doma

Mahabalarao Sampath Halmuthur

Taneja,subhash Chandra

Chandra Taneja Subhash

The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (&#x3b1;-methylene-&#x3b3;-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 &#x3bc;M to 93 &#x3bc;M. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the &#x3b1;,&#x3b2;-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity. 

Spiro derivatives of parthenin as novel anticancer agents

The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)&#x2014;N-benzyl-3-hydroxypyrrolidine and (R)&#x2014;N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)&#x2014;N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.

Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines

The present invention relates to a process for the synthesis of racemic nerol oxide i.e. 3,6-dihydro-4-methyl-2-[2-methyl-1-propenyl)-2H-pyran from monoterpene alcohol nerol i.e. cis-3,7-dimethylocta-2,6-diene-1-ol.

Process for preparation of nerol oxide

The present invention relates to anti-microbial activity of the essential oil of (Nees ex Steud) Wats and the process of isolation of novel sesquiterpene compound which is mainly responsible for the strong anti-microbial/anti-bacterial activity. The present invention particularly relates to anti-bacterial activity of the essential oil and a pure isolate identified as (&plus;)-1-bisabolone of formula 1 against gram positive bacteria from a strain of a grass identified as

(&plus;)-1-Bisabolone isolated from cymbopogon flexuosus and antibacterial activity thereof

The present invention relates to a process for the systhesis of optically enriched dextro- and laevo-rotatory isomers of rose oxide from racemic citronellol. The invention particularly relates to the preparation of optically enriched (&minus;)-(2 S, 4 R)-rose oxide and its isomer (&plus;)-(2 R, 4 S)-rose oxide torn racemic citronellol.

Chemo-enzymatic synthesis of optically enriched rose-oxides

Disclosed herein is a novel fraction comprising a mixture of boswellic acids, wherein the fraction exhibits anti-inflammatory and antiulcerogenic activities. Also disclosed is a novel boswellic acid compound exhibiting anti-inflammatory, antiathritic and antiulcerogenic activities. Also disclosed is a process for isolating a boswellic acid fraction and individual boswellic acids therefrom.

Boswellic acid compositions and preparation thereof

Growing community of inventors

Jammu Tawi, India

Vijay Kumar Sethi