Thermogenesis Corporation

Caridianbct Biotechnologies, LLC

Cesca Therapeutics, Inc.

Vijay Kumar

John Raymond Chapman

Brian K Cinquini

Phillip D Kingsley

Raymond P Goodrich

Shawn D Keil

Robert Owen Lockerbie

Daniel Jason Stein

Brian Robert Rohrs

Vish Bangalore

John R Chapman

Bian K Cinquini

Eric Phillips

A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for dosing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

Apparatus and method for separating and isolating components of a biological fluid

A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light

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Gold River, CA, United States of America

Vijay Kumar