Ranbaxy Laboratories, Inc.

Aurobindo Pharma Limited

Vijay Kumar Handa

Meenakshisunderam Sivakumaran

Ramesh Dandala

Jag Mohan Khanna

Om Dutt Tyagi

Divvela Venkata Naga Srinivasa Rao

Ram Chander Aryan

Vipin Kumar Kaushik

Gyan Chand Yadav

Arun Kumar Gupta

Uthira Kumar

Venkataiah Sunku

Uttam Kumar Ray

Surinder Mohan Gupta

Nittin Maheshwari

Amit Rohatgi

The present invention is directed to a new process of preparing highly pure Florfenicol. The invention is further directed to new oxazolidine derivatives useful in making Florfenicol and processes of making these derivatives. Examples of such intermediates include (4R,5R)-3-acetyl-2,2-dimethyl-4-hydroxymethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine; and (4S,5R)-3-acetyl-2,2-dimethyl-4-fluoromethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine.

Process for preparing florfenicol

The present invention describes an industrially advantageous process to prepare highly pure 1-Methyl-3-phenylpiperazine of Formula Ithat makes use of a novel piperazine derivative, 4-Benzyl-1-methyl-2-oxo-3-phenylpiperazine, represented by Formula II1-Methyl-3-phenylpiperazine is a useful intermediate in the preparation of antidepressant Mirtazapine.

Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate

A process for the preparation of highly pure crystalline form of cefuroxime-1-acetoxyethyl ester (cefuroxime axetil) from cefuroxime by reacting an amine salt of cefuroxime with an esterifying reagent.

Process for the preparation of highly pure crystalline (R,S)&mdash;cefuroxime axetil

The present invention relates to an industrially advantageous method for the purification of Citalopram (Formula I) wherein desmethyl citalopram (Formula II), present in crude Citalopram as an impurity, is methylated to produce pure Citalopram. The resulting Citalopram product is isolated as the base or a pharmaceutically acceptable salt thereof

Preparation of pure citalopram

A process is disclosed for the preparation of 7-amino-3-(2-furanylcarbonylthiomethyl)-3-cephem-4-carboxylic acid (also known as Furaca). The process comprises of the steps of reacting 7-aminocephalosporanic acid with a mixture of 2-thiofuric acid and Boron Trifluoride in a solvent and precipitating Furaca as a solid.

Process for the preparation of furaca

A novel process for the preparation of ceftiofur, a cephalosporin antibiotic useful in the treatment of bovine respiratory disease using a novel bromo or chloro intermediate. the process comprises of the steps of cyclizing a new bromo or chloro intermediate with thiourea in the presence of selected solvents to produce ceftiofur of high purity. A process to prepare such novel bromo and chloro intermediate comprising of the steps of condensing silylated Furaca with 4-(bromo or chloro)-2 methoxyamino-3-oxobutyric acid or its acid halide is also described.

Ceftiofur, its intermediate and a process for the preparation of the same

There is described a process for the preparation of a pure amorphous form of cefuroxime axetil which involves dissolving crystalline cefuroxime axetil in acetic acid including at least 5% v/v water and recovering said amorphous form of cefuroxime axetil from the solution by the addition of additional water, the solution being added all at once to the additional water being present in a volume which is sufficient to precipitate said amorphous cefuroxime axetil.

Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil

There is described a process for the preparation of cefuroxime from predominantly S-cefuroxime axetil, R, S mixture of cefuroxime axetil or R-cefuroxime axetil not meeting the purity criteria. This comprises treating cefuroxime axetil with alkoxides in the presence of a suitable solvent or solvent mixture and isolating cefuroxime from the reaction mixture.

Process for the preparation of cefuroxime

The present invention relates to the preparation of crystalline (Z)-2-(2-tert.-butoxycarbonyl prop-2-oxyimino)-2-(2-triphenylmethylaminothiazol-4-yl) acetic acid of the following formula

Process for the preparation of crystalline (Z)-2-(2-tert.-butoxycarbonylprop-2-oxyimino)-2-(2-triphenylmethylaminothiazol-4-yl) acetic acid in association with N,N-dimethylformamide

A process for preparing certain cephalosporin antibiotics, namely, cefotaxime, cefetemet, and ceftriaxone sodium comprising acylation of 7-amino-3-cephem-4-carboxylic acid derivatives with 2-mercapto-5-methyl-1,3,4-thiadiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-metho xyiminoacetate having the formula: ##STR1##

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Hyderabad Telangana, India

Vijay Kumar Handa