The Salk Institute for Biological Studies

Vihang A Narkar

Ronald Mark Evans

Michael Downes

Ruth T Yu

Reuben J Shaw

Provided herein are methods and compositions for improving muscle performance and increasing endurance. Agonists of AMP-activated protein kinase (AMPK) and agonists of peroxisome proliferator-activated receptor delta (PPAR&#x3b4;) can be used in such treatments.

Methods for enhancing muscle performance and tone

This application provides methods of increasing vascularization, muscle performance, muscle rehabilitation, and/or mitochondrial activity in subjects in need thereof, by administering a therapeutically effective amount of one or more agents that increases ERR&#x3b3; activity to the subject. Such agents can include one or more ERR&#x3b3; agonists. In some examples the method does not require that the subject exercise, and as such, the subject may be sedentary (such as bedridden or in a wheelchair).

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San Diego, CA, United States of America

Vihang A Narkar