The Charles Stark Draper Laboratory, Inc.

Vienna Mott

Jeffrey T Borenstein

Joseph L Charest

Mark Joseph Mescher

Daniel Doty

Nathan Francis Moore

Brett C Isenberg

Hesham Azizgolshani

Brian Cain

Timothy Haggerty

Alla Gimbel

A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.

Multiwell dynamic model for a tumor-immune microenvironment

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Cambridge, MA, United States of America

Vienna Mott