Eli Lilly and Company

Wayne State University

University of Hawai'i

Vien V Khau

Michael J Martinelli

Barry C Peterson

John E Toth

David Lee Varie

Bret E Huff

Marvin M Hansen

Eric D Moher

David W Hoard

Allen R Harkness

Joseph Matthew Pawlak

Joseph M Pawlak

Kevin A Sullivan

Naresh K Nayyar

Process and novel intermediates

A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA.sub.2 and novel intermediates useful in the preparation of such compounds.

Process for preparing 4-substituted-1H-indole-3-glyoxamides

The instant invention provides a novel process for preparing benzyl-substituted rhodanine derivatives. The process is particularly useful for synthesizing the enantiomers of such derivatives. Also provided are novel benzyl-substituted mercaptopropanoic acids and benzyl-substituted thiazolidinones. Such compounds are useful for treating inflammatory bowel disease and, accordingly, the present invention provides a method of treating inflammatory bowel disease in mammals utilizing such novel compounds as well as pharmaceutical compositions containing same.

Process for preparing benzyl-substituted rhodanine derivatives

This invention provides a process for the stereocontrolled synthesis of cis-bicyclic compounds, including cis-hexahydro-6-isoquinolones, cis-dihydroisochromanones, cis-dihydrothiochromanones, and cisbicyclo[4.4.0]dec-3-ene-2-ones.

Stereocontrolled synthesis of cis-bicyclic compounds

This invention provides a process for the synthesis of cis-decahydroisoquinoline-3-carboxylic acids and provides intermediates in the synthesis thereof.

Synthesis of cis-decahydroisoquinoline-3-carboxylic acids

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Carmel, IN, United States of America

Vien V Khau