Massachusetts Institute of Technology

Visterra, Inc.

Harvard College

The Broad Institute, Inc.

Vidya Subramanian

Ram Sasisekharan

Karthik Viswanathan

Venkataramanan Soundararajan

Viswanathan Sasisekharan

S Raguram

Kannan Tharakaraman

Zachary Shriver

Sasisekharan Raguram

Fei Chen

Jesse Engreitz

Sam Rodriques

Sasi Raguram

Andrew Peter Hatas

Devin Quinlan

Jamie Marshall

Eduardo Fleischer

This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use.

Ha binding agents

Described herein are mutations in the CH1/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

Bispecific antibodies having constant region mutations and uses therefor

Provided herein are methods for generating single-cell molecular analysis comprising a) delivering one or more proximity dependent probes to a cell population, wherein each proximity dependent probe comprises a target binding region configured to bind a target RNA and a primer binding site region; b) linking bound proximity dependent probes; c) isolating single cells from the cell population in separate individual discrete volumes, the individual discrete volumes further comprising a primer pair and amplification reagents, wherein the primer pair binds to the primer binding sites of the ligation dependent probes, and wherein at least one primer comprises a barcode sequence that uniquely identifies the individual discrete volume; d) amplifying the ligated probes using the primer pair, wherein the barcode is incorporated into each resulting amplicon; and e) quantifying target RNAs in each individual cell based at least in part on sequencing the resulting amplicons.

Multimodal readouts for quantifying and sequencing nucleic acids in single cells

The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza.

Agents for influenza neutralization

Isolated monoclonal antibodies which bind to Ebola virus glycoprotein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

Antibodies that bind Ebola glycoprotein and uses thereof

HA binding agents

The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.

Engineered polypeptide agents for targeted broad spectrum influenza neutralization

Growing community of inventors

Somerville, MA, United States of America

Vidya Subramanian