Ibio Limited

Fraunhofer USA, Inc.

Thomas Jefferson University

Ibio, Inc. and Fraunhofer USA, Inc.

Vidadi Yusibov

Vadim Mett

Shailaja Rabindran

Oleg Fedorkin

Konstantin Musiychuk

Hilary Koprowski

Douglas Craig Hooper

Burt D Ensley

Anna Modelska

Jessica Chichester

Marina Skarjinskaia

Konstantin Musiychuck

Lauren Goldschmidt

Yoko Shoji

Megan R Carpenter

Zusheng Li

Anna Hull

Tarlan Mammedov

Moneim Shamloul

Alexei Prokhnevsky

Elisabeth Knapp

Joey Norikane

Christine E Farrance

Konstantin A Musiychuk

Valentina Mett

Materials and methods for in vivo de-glycosylation of recombinant N-glycosylated proteins by co-expression with bacterial PNGase F (Peptide: N-glycosidase F) in plants, using a transient expression system are described. Methods are described which, for example, produce recombinant proteins of interest in plants in a non-glycosylated form. A method of expressing active bacterial PNGase F in plants also is provided.

In vivo de-glycosylation of recombinant proteins by co-expression with PNGase F

Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein.

Influenza hemagglutinin antibodies, compositions and related methods

The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants.

System for expression of genes in plants

The present invention provides novel antimicrobial bacteria strains and uses thereof to prepare novel antimicrobial agents. Also provided are the novel antimicrobial agents.

Antimicrobial bacteria strains and uses thereof

The present invention relates to novel virus-like particles (VLPs) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus. The target polypeptide may be antigenic or therapeutic. The first and the second plant enveloped viruses may be the same. Either plant enveloped virus may be a plant rhabdovirus. Also provided are methods of making and using the VLPs.

Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof

Antibodies against influenza neuraminidase, compositions containing the antibodies, and methods of using the antibodies are provided herein.

Humanized neuraminidase antibody and methods of use thereof

A plant growth container includes a tray, an inlet channel in the tray, a growth media retainer in the tray, one or more protrusions within the growth media retainer, an outlet channel connected to the growth media retainer, and a lid capable of being fixedly attached to the tray. The tray can be used in a hydroponic growth system for plants, where the system includes a container for growing plants. The container includes a tray, an inlet channel in the tray, a growth media retainer in the tray connected to the inlet channel, one or more protrusions in the growth media retainer, the protrusions capable of securing growth media from lateral movement, an outlet channel connected to the growth media retainer, and a lid. The system may include a reservoir for holding a liquid and a pump capable of pumping the liquid from the reservoir to the container.

Cascading plant growth system and plant growth tray

Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.

Recombinant carrier molecule for expression, delivery and purification of target polypeptides

Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds toprotective antigen; and cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds tolethal factor. The invention further provides expression vectors that contain one or more cDNAs isolated according to the methods of the invention, host cells expressing one or more inventive cDNAs, and transgenic plants and animals that express one or more inventive cDNAs. In certain embodiments of the invention the expression system is a plant-based expression system. The invention further provides antibody compositions comprising one or more antibodies produced by expressing a cDNA isolated according to the methods of the invention in a suitable expression system. Additionally encompassed in the invention are kits containing one or more of provided compositions, as well as methods of production and use of provided compositions.

Compositions and methods for production of immunoglobulins

The present invention provides antigens and vaccines useful in prevention of infection by. The present invention provides pharmaceutical compositions of such antigens and/or vaccines. The present invention provides methods for the production ofprotein antigens in plants, as well as methods for their use in the treatment and/or prevention ofinfection.

[object Object]

The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection byprotozoa. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions.

Growing community of inventors

Havertown, PA, United States of America

Vidadi Yusibov