Academisch Medisch Centrum Bij De Universiteit Van Amsterdam

Victorine Augustine Pinas

Bertha Louise Frederike Van Eck-Smit

Albert Dirk Windhorst

The invention is directed to radiolabelled MMP selective compounds, a processes for the preparation thereof, and uses thereof. The derivatives of the invention have formula (I) wherein Y represents O, CH, (CH), S, NH, or C(&#x2550;O)NH; X represents 1-5 substituents, wherein said substituents can be the same or different and wherein at least one of said substituents comprises a radioisotope suitable for PET and/or SPECT and/or a &#x3b2;-emitter; Z is S; Q is chosen from the group consisting of 3-pyridyl and carboxyl; and R is chosen from the group consisting of C(&#x2550;O)&#x2014;NH&#x2014;OH, (II), (III, (IV). The MMP selective compounds of the invention are selective for MMPs and can be used for the identification and treatment of unstable atherosclerotic plaques. 

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Victorine Augustine Pinas