United States of America As Represented by the Secretary of the Air Force

Washington University

Victor Mark Birman

Guy M Genin

Stavros Thomopoulos

Larry W Byrd

Stephen Linderman

Kollbe Ahn

Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including CTGF/CCN2, or cells.

Compostions and methods for tissue repair

A thermal protection system capable of withstanding impact loads without a detrimental effect to its main function, i.e. a protection of the vehicle from high temperature during re-entry or flight in the atmosphere. The system consists of the outer ceramic matrix composite shield, a ceramic tile sandwiched between the shield and the skin of the vehicle and fasteners joining the system and the protected structure. The ceramic matrix composite fasteners are capable of working in the same high-temperature environment as the rest of thermal protection system. They are also strong and stiff due to the presence of ceramic fibers. Cracks in the outer shield produced by impact cannot propagate into the ceramic tile since the shield and tile materials are discontinuous along the interface. The tile cannot disintegrate from the vehicle since it is pressed to its skin by the outer shield. The system can easily be disassembled for inspection and/or repair.

Replaceable impact resistant thermal protection system

Growing community of inventors

Chesterfield, MO, United States of America

Victor Mark Birman