Monsanto Technology LLC

Monsanto Company

Harvard College

Victor M Guzov

Leigh H English

Stanislaw Flasinski

James Arthur Baum

Jay Paul Morgenstern

Sara Ann Salvador

Crystal L Dart

James Kevin Roberts

Arlene R Howe

Xiaoran Fu

Thomas Cerruti

Jinling Hung Wang

Thomas M Malvar

Deborah G Rucker

Artem G Evdokimov

Catherine Alice Chay

David Joseph Bowen

Uma R Kesanapalli

Ty T Vaughn

Jason S Milligan

Robert M McCarroll

William P Clinton

David J Chi

Temple F Smith

Moritz W F Von Rechenberg

Kevin A Jarrell

Carlos E Soto

Collin M Stultz

Brian M Turczyk

Farhad Moshiri

Meiying Zheng

Sakuntala Sivasupramaniam

Qing Huai

Renata Bolognesi

Edward Kraft

David R Liu

Larry A Gilbertson

Sergey Ivashuta

Ahmed Hussein Badran

Prashanth Vishwanath

Brian Edward Weiner

Melissa Kemp

Jeff Nageotte

Tom Malvar

Parthasarathy Ramaseshadri

Byron V Olsen

Yifei Kong

Melissa M Kemp

Jeffrey A Haas

Timothy K Ball

Thomas A Cerruti

Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.

Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests

Disclosed herein are nucleotide sequences encoding an insecticidal protein exhibiting Lepidopteran inhibitory activity, as well as novel insecticidal proteins referred to herein as a BCW 001, BCW 002, BCW 003, and BCW toxic protein-containing chimeras and BCW toxin insecticide, transgenic plants expressing the chimeras or the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.

Pesticidal toxin proteins active againstinsects

Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests. Methods and compositions for producing and using such proteins are also provided.

Multi functional toxins

Disclosed herein are nucleotide sequences encoding an insecticidal protein exhibitinginhibitory activity, as well as novel insecticidal proteins referred to herein as a BCW 001, BCW 002, BCW 003, and BCW toxic protein-containing chimeras and BCW toxin insecticide, transgenic plants expressing the chimeras or the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.

Pesticidal toxin proteins active against lepidopteran insects

The disclosure provides amino acid sequence variants of(Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.

Evolution oftoxins

Chimeric insecticidal proteins toxic or inhibitory to Lepidopteran pests

The invention relates to identification and characterization of recombinant DNA and polypeptides for specific Bt toxin receptors. In particular, the Bt toxin receptors of the invention include those derived from the Lepidopteran super family including the species, and. The receptors of the invention further include those derived from the Coleopteran super family and particularly from the species. The recombinant DNA and polypeptides so provided are useful in the identification and design of novel Bt toxin receptor ligands including novel or improved insecticidal toxins for use in a variety of agricultural applications. Materials and methods for identifying novel toxins are also disclosed herein. The invention also provides methods for selecting toxins to combine to control insect populations by manipulating Bt toxin receptor.

toxin receptors and uses thereof

Growing community of inventors

Cambridge, MA, United States of America

Victor M Guzov