University of Michigan

Victor M Elner

Howard R Petty

Gerard A Mourou

Xinbing Liu

Kanishka T Jayasundera

Matthew K Johnson-Roberson

Peter P Pronko

Daniel L Albertus

Ron Kurtz

Nathan T Patel

Christopher R Ranella

Jeffrey A Squier

Subrata K Dutta

Detao Du

Paul R Lichter

A method for automatically measuring changes in retinal, retinal pigment epithelial, or choroidal disease includes retrieving a set of images of a fundus and selecting a plurality of images from the set of images. The plurality of images are co-registered and pre-processed such that the quality, contrast, and gain of each of the plurality of images is made similar. Then, a comparison is made between the plurality of images to determine a change in retinal, retinal pigment epithelial, or choroidal disease, wherein the change in retinal, retinal pigment epithelial, or choroidal disease is determined based on various disease metrics. Finally, an indication of the change in retinal, retinal pigment epithelial, or choroidal disease is generated for display to a user on a computing device.

Automated measurement of changes in retinal, retinal pigment epithelial, or choroidal disease

A method and apparatus for measuring the retinal auto-fluorescence of a subject retina includes an excitation light source for providing an excitation light at a wavelength of at least 450 nm and an image capture device for recording an ocular auto-fluorescence signal generated in response to the excitation light. The image capture device includes a filter for reducing background non-signal wavelengths from the ocular auto-fluorescence signal and an image intensifier for increasing the ocular auto-fluorescence signal strength. The method and apparatus may further include a processor that analyzes the ocular auto-fluorescence signal to determine a contrast change or pattern to thereby detect retinal disease or damage. The processor may compare the images with control images, past images of the same eye or other diagnostic modalities such as fundus photography, angiography, or visual field testing to detect the retinal disease or damage.

Method of evaluating metabolism of the eye

In one aspect the invention provides a method for laser induced breakdown of a material with a pulsed laser beam where the material is characterized by a relationship of fluence breakdown threshold (F.sub.th) versus laser beam pulse width (T) that exhibits an abrupt, rapid, and distinct change or at least a clearly detectable and distinct change in slope at a predetermined laser pulse width value. The method comprises generating a beam of laser pulses in which each pulse has a pulse width equal to or less than the predetermined laser pulse width value. The beam is focused to a point at or beneath the surface of a material where laser induced breakdown is desired. The beam may be used in combination with a mask in the beam path. The beam or mask may be moved in the x, y, and Z directions to produce desired features. The technique can produce features smaller than the spot size and Rayleigh range due to enhanced damage threshold accuracy in the short pulse regime.

Method for controlling configuration of laser induced breakdown and

Growing community of inventors

Ann Arbor, MI, United States of America

Victor M Elner