Molecular Partners Ag

F. Hoffmann-la Roche Ag

Victor Levitsky

Hans Kaspar Binz

Patrik Forrer

Marcel Walser

Johannes Schilling

Natalia Venetz

Guy Georges

Stefan Seeber

Valeria Lifke

Barbara Weiser

Adrian Zwick

Ildiko Wuensche

Valérie Perrine Calabro

Sebastian Grimm

Christian Reichen

Matteo Bianchi

Bernd Schlereth

Nicolo Rigamonti

Clara Domke

Niina Elisabet Veitonmäki

Nina Reschke

Pamela Anna Trail Smith

The present invention relates to designed ankyrin repeat domains with altered surface residues, as well as to proteins comprising such a designed ankyrin repeat domain, nucleic acids encoding such domains or proteins, methods of preparing such proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.

Designed ankyrin repeat domains with altered surface residues

The present disclosure relates to multispecific proteins comprising designed ankyrin repeat domains with binding specificity for different targets, such as, e.g. CD40 and FAP. In addition, the present disclosure relates to nucleic acids encoding such multispecific proteins, pharmaceutical compositions comprising such multispecific proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, such as cancer, in a mammal, including a human.

Multispecific proteins

The present invention relates to recombinant multi-specific proteins comprising binding agents with binding specificity for different targets, such as, e.g. CD3, CD33, CD123 and CD70. In addition, the invention relates to nucleic acids encoding such multi-specific proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, such as cancer, e.g. acute myeloid leukaemia (AML), in a mammal, including a human.

DARPin based multi-specific t-cell engagers

Growing community of inventors

Birmensdorf, Switzerland

Victor Levitsky