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Societe Anonyme Dite: Laboratoire L. Lafon

Laboratoire L. Lafon

Societe Anonyme Dite: Orsymonde

Victor Lafon

Louis L Lafon

The compound (3,4-Dichlorophenylsulphinyl)-acetamidoxime, of the structural formula: ##STR1## and its addition salts with acids. These compounds are useful in therapy as substances acting on the central nervous system.

Sedative compositions containing

The sulphur- and oxygen-containing diaryl compounds of the formula: ##STR1## in which A and B, which may be the same or different, represent O, S, SO or SO.sub.2, Alk is a C.sub.1 -C.sub.4 hydrocarbon radical with a straight or branched chain, R represents COOH, an esterified COOH group, a carboxylic amide group, OH, O-SO.sub.2 CH.sub.3, NH.sub.2, NHR.sub.1, NR.sub.1 R.sub.2, NHZOH, NHZNR.sub.1 R.sub.2, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH or 2-.DELTA..sup.2 -imidazolinyl, Z is a C.sub.2 -C.sub.4 hydrocarbon radical with a straight or branched chain, and R.sub.1 and R.sub.2 each represent a C.sub.1 -C.sub.3 lower alkyl group, or together form, with the nitrogen atom to which they are linked, a N-heterocyclic group of 5 to 7 ring atoms which can be substituted and can comprise a second hetero-atom, and their addition salts with bases when R is COOH, and their addition salts with acids when R is a basic radical, are useful pharmacological agents in the treatment of circulatory complaints such as cardio-vascular illnesses.

Sulphur- and oxygen-containing diaryl compounds

Phenylsulphinyl derivatives of the formula ##STR1## in which R.sub.1 represents hydrogen or one or more identical or different substituents, Alk represents a C.sub.2 -C.sub.4 hydrocarbon radical with a linear or branched chain, and A represents C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH, C(.dbd.O)NHOH, or ##STR2## where Z is CH.sub.2 CH.sub.2 or CH.sub.2 CH.sub.2 CH.sub.2 and R is H, CH.sub.2 COOH, CH(CH.sub.3)COOH or C(CH.sub.3).sub.2 COOH, and their addition salts, have interesting therapeutic properties on the central nervous system as anxiolytic agents and/or analgesic and anti-inflammatory agents.

Cyclic phenylsulphinyl-amidine derivatives

The invention provides new compounds of the formula:

Sulphur containing arylamine derivatives

Phenylsulphinyl derivatives of the formula ##STR1## in which R.sub.1 represents hydrogen or one or more identical or different substituents, Alk represents a C.sub.2 -C.sub.4 hydrocarbon radical with a linear or branched chain, and A represents C(=NH)NH.sub.2, C(=NH)NHOH, C(=O)NHOH, or ##STR2## where Z is CH.sub.2 CH.sub.2 or CH.sub.2 CH.sub.2 CH.sub.2 and R is H, CH.sub.2 COOH, CH(CH.sub.3)COOH or C(CH.sub.3).sub.2 COOH, and their addition salts, have interesting therapeutic properties on the central nervous system as anxiolytic agents and/or analgesic and anti-inflammatory agents.

Phenylsulphinyl-amidine derivatives

Lyophilised oil-in-water emulsions and suspensions are useful as compositions for dermatological, cosmetological, buccal, and dental use having the advantage over conventional compositions of lower bulk and better storage stability.

Growing community of inventors

Paris, France

Victor Lafon