The Dupont Merck Pharmaceutical Company

E.i. Dupont De Nemours and Company

Victor J Nickolson

Melvyn J Myers

Richard A Earl

Victor J De Noble

Kimi F De Noble

Cognitive defeciencies or neurological dysfunction in mammals are treated with .alpha.,.alpha.-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: ##STR1## or a salt thereof wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is .alpha. to at least one additional aromatic ring or heteroaromatic ring fused to the first ring;

.alpha.,.alpha.-disubstituted aromatics and heteroaromatics as cognition

.alpha., .alpha.-disubstituted aromatics and heteroaromatics as

This disclosure relates to a method of treating a neurological dysfunction in a mammal using a combination of at least one neurotransmitter enhancer and at least one serotonin receptor antagonist.

Method of treating neurological dysfunction using neutrotransmitter

Cognitive deficiencies and/or neurological function deficits and/or mood and/or mental disturbances are treated by the administration of 3,3-disubstituted indolines. The indolines have the formula: ##STR1## wherein: p is 0 or 1;

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Hermelijnedreef, Netherlands

Victor J Nickolson