E.i. Dupont De Nemours and Company

The Dupont Merck Pharmaceutical Company

Victor J De Noble

John J Duncia

Pancras C Wong

Andrew T Chiu

Richard A Earl

Melvyn J Myers

Victor J Nickolson

Kimi F De Noble

Imidazole compounds such as 5-[4-(3-(N-isopropylamino)hydroxypropoxy)indole-2-carboxamidomethyl]-2-n-b utyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloroimidazole and their pharmaceutically suitable salts are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.

Treatment of central nervous disorders with imidazole compounds

This disclosure relates to a method of treating a neurological dysfunction in a mammal using a combination of at least one neurotransmitter enhancer and at least one serotonin receptor antagonist.

Method of treating neurological dysfunction using neutrotransmitter

Substituted pyrazole, pyrrole and triazole angiotensin-II-1 receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.

Treatment of central nervous system disorders with pyrazole, pyrrole and

Substituted benzimidazoles such as 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-chlorobenzimidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.

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Newark, DE, United States of America

Victor J De Noble