Warner-lambert Company

Other

Pfizer Corporation

Victor Fedij

Bruce A Lefker

Lain-Yen Hu

James N Wemple

Stephen Douglas Barrett

Mark J Suto

Karen Elaine Sexton

James R Zeller

Raj Kumar Raheja

Donna Michele Iula

Jennifer Ann Van Camp

Denis Martin Sobieray

Timothy L Stuk

Bradley Dean Tait

Daniel Y Du

Christopher Andrew Gajda

Brian Keith Huckabee

Huangshu Lei

Kenneth Thomas Porter

Yvonne Dorothy Smith

Brian Stuart Moon

Bruce Allen Lefker

The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Androgen modulators

The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

The present invention relates to methods of making dihydropyrone HIV inhibitors.

Methods of making dihydropyrone HIV protease inhibitors

Chiral 3-cyanopyrrolidines of the following formula are disclosed, wherein R' is as defined herein. The compounds are useful as intermediates for naphthyridine and quinoline antibiotics. ##STR1##

Chiral 3-cyano-1-substituted-pyrrolidines

The process for the preparation of chiral 3-(1-amino-1,1-bisalkylmethyl)-1-substituted-pyrrolidines used as key intermediates for the preparation of naphthyridine and quinolone antibacterial agents which comprises reacting readily available chiral 1-substituted-3-pyrrolidinols to their corresponding chiral sulfonate esters; converting the sulfonate esters to chiral 1-substituted-3-cyanopyrrolidines having an inverse configuration, and then dialkylating the chiral cyanopyrrolidines with alkyl lithium in the presence of a Lewis acid without racemization at the asymmetric carbon atom is described.

Process for chiral

This disclosure depicts a novel apparatus for providing protection to armored personnel carriers such as tanks, or other military vehicles. The invention comprises a series of rectangular armor plates mounted to the surface area of the vehicle. The armor plates adjacent one another and each plate is secured to the tank surface by a threaded fastener. The threaded fasteners maintain the plates a predetermined distance from the tank surface and maintains the plates in a substantially parallel relationship to the surface of the tank wall. Each plate has three separate tiles adhered together, one tile comprising a steel material, one tile a soft material and one tile a thermally dissipating ceramic. The means for mounting the plates to the tank surface are designed such that the energy required to break the threaded fastener upon impact by a projectile is less than the energy required for the projectile to penetrate the plate.

Active armor

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Brighton, MI, United States of America

Victor Fedij