Johns Hopkins University

Victor E Velculesu

Bert Vogelstein

Kenneth W Kinzler

Sian Jones

D Williams Parsons

Tobias Sjoblom

Diana Mandelker

Laura D Wood

Thomas Barber

Jimmy Lin

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of &#x2dc;90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Consensus coding sequences of human breast and colorectal cancers

Growing community of inventors

Baltimore, MD, United States of America

Victor E Velculesu