General Electric Company

Baker Hughes, a Ge Compnay, LLC

Ge Healthcare Limited

Ge Healthcare UK Limited

Victor Donald Samper

Christoph Boeld

Christian Friedrich Peter Rensch

Marko Klaus Baller

Christian Rensch

Ruben Julian Horvath-Klein

Ruben Julian Salvamoser

Mark Ronald Lynass

Ronghui Zhou

Pekka Tapani Sipilä

Alok Mani Srivastava

Christof Martin Sihler

Glenn Scott Claydon

Simon Herbert Schramm

Shankar Chandrasekaran

Anis Zribi

Sandip Maity

Stacey Joy Kennerly

Min-Yi Shih

Shivappa Ningappa Goravar

Ayan Banerjee

David Cecil Hays

Long Que

Xavier Franci

Philipp Lang

Dirk Lange

Colin Steel

Xavier Yvon André Franci

Robin Fortt

Stefan Riese

Willam Scott Sutherland

Klaus Franz Otto Raum

Christian Friedrich Rensch

Johan Urban Ulin

Johan Urban Ingemar Ulin

A sensor for sensing stress in a ferromagnetic material includes a non-magnetic substrate. The substrate has a first surface and a second surface opposite the first surface. A first coil is attached to or formed on the first surface of the substrate. The first coil is configured to induce a magnetic flux in the ferromagnetic material being driven by an alternating current (AC) signal. At least one second coil is attached to or formed on the first surface of the substrate. The at least one second coil is spaced from the first coil. In addition, the second coil is configured to detect changes in the magnetic flux induced in the ferromagnetic material.

Non-contact magnetostrictive sensors and methods of operation of such sensors

Described herein is a system for on-demand synthesis/analysis of compounds and/or diagnostic applications. In general, any application that requires a low-cost binary switch valve array for fast (&#x3c;100 ms) switching of gases or liquids, in a spatially compact format, is compatible with the system described herein.

Compact valve array with actuation system

Fluid transport approaches are described that operate without the need for precise displacement of an actuator and with little or no sensing in the flow path. In certain implementations, a gas phase in a fluid reservoir is compressed by a pressure source such that releasing the pressure, such as by opening a valve to an intermediary conduit, displaces fluid to the intermediary chamber. Closing that fluid path and opening a different fluid path to a chamber at ambient temperature causes the fluid to be displaced to the chamber.

Gas driven fluid transport

A microfluidic device for storing a reagent includes a single unit includes a first portion having a reagent storage chamber configured to hold a reagent. The device also includes a second portion having a reaction chamber configured to support the reagent during a reaction process to form a product. The device also includes a valve configured to isolate the reagent storage compartment from the reaction chamber when the valve is in a closed state.

Systems and methods for reagent storage

Radiation-sensitive material embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. There is provided a device comprising means for the introduction of a precursor compound, means for the introduction of a radionuclide, a reaction vessel for reacting said precursor compound and said suitable source of a radionuclide to obtain a radiolabelled compound, and one or more pieces of radiation-sensitive material embedded into said device wherein at least one of said pieces is positioned to be exposed to radioactivity associated with said radiolabelled compound.

Disposable radiochemistry device with radiation dose recordal

Techniques and devices are provided related to a handling system for cassettes for radiolabeled compound synthesis that include a magazine that is unshielded and that is configured to receive a plurality of microfluidic synthesis cassettes. In one embodiment, the plurality of microfluidic synthesis cassettes include nonradioactive reagents to generate a radiolabeled compound when reacted with a radioactive species. In this manner, a cassette handling device may be stored unshielded and may be coupled to a cassette handling platform to allow advancement of the plurality of microfluidic synthesis cassettes into the cassette handling platform and, in turn, a shielded radiosynthesis machine.

Microfluidic handling system

Devices and methods for electrochemical phase transfer utilize at least one electrode formed from either glassy carbon or a carbon and polymer composite. The device includes a device housing defining an inlet port (), an outlet port () and an elongate fluid passageway () extending therebetween. A capture electrode () and a counter electrode are positioned within said housing such that the fluid passageway extends between the capture and counter electrodes.

Electrochemical phase transfer devices and methods

A method includes flowing a liquid into a channel of a microfluidic cassette filled with a gas. The channel includes an inlet section and an outlet section. The method also includes detecting the liquid, the gas, or a combination thereof at a measuring location within the inlet section. The measuring location has a first sensor that may detect a signal indicative of a presence of the liquid, the gas, or a combination thereof. The method also includes compressing the gas, determining a pressure change of the gas within the channel, and determining a volume of the liquid within the channel based on the pressure change of the gas.

Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure

Techniques and devices are provided related to insert assemblies that may be used in conjunction with microfluidic devices. In one embodiment, the insert assemblies include a functional material, such as a solid stationary phase, that may be coupled to a microfluidic pathway via the insert assembly. In this manner, solid stationary phase materials that may be challenging to directly apply to a microfluidic device may be separately enclosed inside the insert element prior to assembly into a microfluidic device, such as a microfluidic chip.

Insert assembly for a microfluidic device

A microfluidic chip includes a plurality of reagent sources for a feeding a plurality of reagents, each reagent source feeding a corresponding reagent among the plurality of reagents. A macro-chamber receives one or more reagents among the plurality of reagents from the plurality of reagent sources. A microfluidic reactor is coupled to the macro-chamber and the plurality of reagent sources and configured to receive two or more reagents among the plurality of reagents from at least one of the macro-chamber, the plurality of reagent sources, and react the two or more reagents to generate a reaction content.

Microfluidic chip and a related method thereof

A microfluidic device includes a plurality of reagent sources for a feeding a plurality of reagents, each reagent source feeding a corresponding reagent among the plurality of reagents. A macro-chamber receives one or more reagents among the plurality of reagents from the plurality of reagent sources. A microfluidic reactor is coupled to the macro-chamber and the plurality of reagent sources and configured to receive one or more reagents among the plurality of reagents from at least one of the macro-chamber, the plurality of reagent sources, and react the one or more reagents to generate reaction content. The macro-chamber is further configured to receive the reaction content from the microfluidic reactor. A system configured to control at least one of flow of a dry gas in and out of the macro-chamber, surface area of at least one of the one or more reagents, and the reaction content in the macro-chamber.

Microfluidic device and a related method thereof

A fluid connector device is provided. The fluid connector device includes a coupling substrate having a conformal recess, a reconnectable fitting disposed in the recess to provide a first passageway, and a force applying element operatively coupled to the reconnectable fitting, or the coupling substrate, or both the reconnectable fitting and the coupling substrate to at least partially provide a sealing force between the reconnectable fitting and the coupling substrate, wherein at least one of the force applying element, the reconnectable fitting, and the coupling substrate comprises one or more degrees of freedom for self alignment of the reconnectable fitting and the conformal recess.

Fluid connector devices and methods of making and using the same

An interfacing cap for a reagent storage vessel is provided. The interfacing cap comprises a partitioning element having a structure corresponding to an opening of the reagent storage vessel, a projection fitting disposed on the partitioning element, a holder element, and a puncturing element coupled to the projection fitting.

Interfacing caps for microfluidic devices and methods of making and using the same

A microvalve assembly () includes an elongate valve body () having opposed first and second major surfaces, the first major surface defining a valve recess () and the second major surface defining first and second fluid ports (). Both the fluid input port and the fluid output port extend in fluid communication with the valve recess. A gasket () is freely positioned within the valve recess so as to extend in overlying registry with either or both of fluid ports. A valve cover () is bonded to the valve body and includes a first planar surface positioned in overlying registry with the valve recess so as to enclose the gasket therein. The valve cover is deflectable into the valve recess so as to cause the gasket to seal at least one of the fluid ports.

Growing community of inventors

Kirchseeon, Germany

Victor Donald Samper