National Institutes of Health, a Component of the US Dept. of Health & Human Services

Victor Chernomordik

Amir H Gandjbakhche

Paul Reed Smith

Edward Wellner

David Hattery

Jim Mulshine

Paul D Smith

Albert Claude Boccara

Alexander Sviridov

Moinuddin Hassan

Zachary Ulissi

A polarization-based colposcopy apparatus includes a polarization exchanging beam splitter pair oriented so that s- and p-polarizations are exchanged. An optical flux from a specimen is directed through the pair, and orthogonal components thereof are alternately or selectively coupled to an array detector. The detected images are processed based on image correlations to reveal specimen structures.

Polarimetric accessory for colposcope

The invention provides a device and method for monitoring inflammation of the epithelium. The device consists of a head region, a handle region and an optical bundle. At least two of the optical fibers in the bundle are utilized as a source of radiation, these two fibers are at two different angles from normal. At least one of the other optical fibers is utilized as a detector for the reflected radiation, or alternatively an image guide can be used as the detector. The device of the invention can be part of an external or internal system that can include a light source, the device, a multiplexer, a spectrometer, and a computer for data analysis. The method of the invention allows for the detection and monitoring of general inflammation of the oral epithelium. The inflammation of the epithelium can be detected or monitored to diagnose diseases of the oral epithelium, monitor such diseases, monitor treatment of such diseases, or pre-screen for and monitor preventative treatments of such diseases.

Methods of detecting inflammation of an epithelium layer in the oral region with a probe using diffuse-reflectance spectroscopy

Probe using diffuse-reflectance spectroscopy

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Rockville, MD, United States of America

Victor Chernomordik