Biochemie S.a.

Sandoz Ag

Biochemie Gesellschaft M.b.h

Biochemie Gmbh

Victor Centellas

Jos&eacute; Diago

Johannes Ludescher

Immaculada Bosch

Rafael Garcia

Jose Diago

José Diago

Joan Cabre

Asuncion Esteve

Marta Poch

Joan Serrat

Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.

Macrolide solvates

Azithromycin in the form of a stable monohydrate and processes for the preparation of azithromycin in the form of an, e.g. stable, monohydrate.

Macrolides

The present invention relates to a process for the production of clarithromycin from an aqueous medium in anhydrous form and in the form of a hydrate.

Macrolide intermediates in the preparation of clarithromycin

Erythromycin A oxime in the form of a hemihydrate.

Erthromycin a oxime solvates

A process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent in non-halogenated solvent; and azithromycin which is free from halogenated organic solvent in a stable anhydrous form; or in the form of a solvate with non-halogenated solvent with the exception of water.

Macrolide production

Silylation process

A process for recovering 2,2-dimethylpropanoic acid in highly pure form from a mixture of 2,2-dimethylpropanoic acid and impurities which may be obtained in the production of a beta lactam antibiotic, by degrading impurities and separating off the volatile fragments.

Growing community of inventors

Cardedeu/Barcelona, Spain

Victor Centellas