Powervision, Inc.

Dnae Group Holdings Limited

Indigo Medical, Inc.

Endovasix, Inc.

Dna Electronics Limited

Other

Nanomr, Inc.

University of California

Pearl Technology Holdings, LLC

Abqmr, Inc.

Armonica Technologies, Inc.

Light Dimensions, Inc.

Victor C Esch

Sergey A Dryga

Eddie W Adams

Lisa-Jo Ann Clarizia

Ravil A Sitdikov

Thearith H Ung

John Anthony Scholl

Barry Cheskin

Luiz B Da Silva

Quang Q Tran

Stephanos Papademetriou

Marc-Alan Levine

Stephen J Hebert

David John Smith

William James Evans

Henry H Wu

Andrew Frederick McDowell

Patrick Myall

Eduardo U Sucgang

Daren L Stewart

Kelly Cox

Bill Evans

Thomas Henning

Yefim Gelfond

Terry Smiley

R Rox Anderson

John H Shadduck

Terah Whiting Smiley

Denise Horrilleno Burns

Peter M Celliers

Steven R Visuri

Richard A London

Richard G Saul

Magdalena A Torrance

David K Aley

Erik J Smith

Steven Roy Julien Brueck

Claudio Argento

William J Benett

Paul J Weber

Alexander M Rubenchik

Alexander Neumann

Laurel Sillerud

Donald Carrol Stenger

Kirsten L Valley

Colin W Dykes

Meghan E Norvell

Eiichi Fukushima

James H Macemon

Duncan J Maitland, Iv

Xin Jin

T Debuene Chang

Gilbert W Collins

Joseph D Kilkenny

Jonathan Hares

Estela D Gatchalian

Paul S Jackson

Kathryn Broughton

Horst R Adam

Marc P Maisel

Joseph Robert Rimsa

Alexandra Barr

Jaclyn Vandervest

Andrew F Mcdowell

Denise H Burns

The invention generally relates to improved enhancement structures for use in surface-enhanced Raman scattering (SERS) and/or surface-enhanced fluorescence-based analysis.

Enhancement structures for surface-enhanced Raman scattering

The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample.

Separating target analytes using alternating magnetic fields

The invention generally relates to a system for isolating or separating a target from a sample. In certain aspects, processes performed by the target capture system include introducing a plurality of magnetic particles, in which a plurality of the particles include at least one binding moiety specific to a target, into a sample to form at least one target/particle complex and applying a magnetic field to isolate the magnetic particle/target complexes from the sample. The process starts at inputting a sample into the system and ends at delivering a capture target or nucleic acids of the target into a container for further analysis.

Target capture system

The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a pathogen from a sample that involve obtaining a sample including a pathogen, conducting an assay that isolates the pathogen from the sample, culturing the isolated pathogen for at most about 24 hrs, and analyzing the pathogen.

Analyzing bacteria without culturing

The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.

Methods for isolating a target analyte from a heterogenous sample

Methods of adjusting an intraocular lens after implantation. In some embodiments the methods include positioning an accommodating intraocular lens within an eye, the intraocular lens comprising an optic portion in fluid communication with a peripheral chamber, wherein movement of a fluid between the peripheral chamber and the optic portion in response to ciliary muscle movement changes the optical power of the lens, and reducing a power of the intraocular lens by causing the fluid to move between the optic portion and the peripheral chamber, wherein the reduction in power of the intraocular lens is not in response to ciliary muscle movement, and wherein the positioning step occurs prior to reducing the power.

Post-implant accommodating lens modification

Methods for isolating a target analyte from a heterogeneous sample

The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample.

Extracting low concentrations of bacteria from a sample

The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.

Compositions for isolating a target analyte from a heterogeneous sample

Growing community of inventors

Albuquerque, NM, United States of America

Victor C Esch