Genetics Institute, Inc.

Other

Harvard College

Genetics, Institute Institute, LLC.

Vicki A Rosen

John Martin Wozney

Elizabeth A Wang

Anthony J Celeste

Neil M Wolfman

Douglas A Melton

Gerald H Thomsen

Gary Hattersley

Jeffrey R Song

Elisabeth Ann Morris

R Scott Thies

Scott R Thies

Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.

Tendon-inducing methods

Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

BMP products

Methods of treatment of periodontal disease

Tendon-inducing compositions

Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.

BMP-6 proteins

Purified BMP-3 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

Bone morphogenetic protein-3 and compositions

Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.

BMP-9 compositions

BMP-4 products

BMP-3 products

Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.

The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.

Growing community of inventors

Brookline, MA, United States of America

Vicki A Rosen