Massachusetts Institute of Technology

Novartis Ag

Veysel Kayser

Bernhardt Levy Trout

Bernhard Helk

Vladimir Voynov

Naresh Chennamsetty

The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.

Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor

The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.

Immunoglobulins with reduced aggregation

The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.

Growing community of inventors

Cambridge, MA, United States of America

Veysel Kayser