Ustav Organicke Chemie a Biochemie Akademie Ved Cr, V.v.i.

Fyziologicky Ustav Akademie Ved Cr, V.v.i.

Veronika Prazienkova

Lenka Maletinska

Blanka Zelezna

Jaroslav Kunes

Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.

Growing community of inventors

Tabor, Czechia

Veronika Prazienkova