International Minerals & Chemical Corp.

Angus Chemical Company

Imc Chemical Group, Inc.

Vernon V Young

David R Bright

Robert D Williams

Jerome L Martin

Richard E Ivy

John S Kosewicz

Frederick William Schmitz

A process for promoting growth and feed efficiency in food producing animals is provided by administering to such animals, growth promoting amounts of certain forms of lysocellin, including the free acid and physiologically-acceptable salts thereof. Metal complexes of lysocellin can be prepared by adding the appropriate soluble metal salts to a fermentation beer containing lysocellin to thereby form an insoluble, recoverable biomass containing the desired growth-promoting metal salt complex of lysocellin for use in the process herein.

Lysocellin-containing feed efficiency-enhancing animal feed

Crystalline lysocellin compositions, and method of making them. These compounds are useful for promoting growth and feed efficiency in food producing mammals by administering growth promoting amounts of the compounds to such mammals. In particular, the crystalline free acid and the crystalline zinc, copper and manganese of lysocellin can be made according to the disclosed methods.

Crystalline lysocellin compositions and method of making

A growth promoting and feed efficiency-enhancing amount of a lysocellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts thereof is administered to a food-producing animal selected from the group consisting of ruminants, swine and poultry in a process for promoting growth and enhancing feed efficiency of such a food-producing animal. A feed supplement for a food-producing animal, the feed supplement being capable of increasing the rate of growth of the animal when supplied in the animal's feed on a regular basis during the animal's normal growth period, and which is also capable of enhancing feed efficiency of the animal, includes a mixture of a basal feed material for a food-producing animal selected from the group consisting of ruminants, swine and poultry, and a growth rate-increasing and feed efficiency-enhancing amount of a lyoscellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts thereof.

Lysocellin-containing composition and process for promoting growth and

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating ingestations of the pinworms Syphacia obscelata and Aspicularis tetraptera in mammals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

Quinoxaline adducts useful as anthelmintics

Antibiotic-metal complexes contain bacitracin, a non-toxic, complex-forming metal and a polyether antibiotic are disclosed. The complexes are useful (1) for promoting growth in poultry and mammals, (2) for controlling swine dysentery, (3) modifying rumen fluid by decreasing the acetate to propionate (A/P) ratio, (4) controlling coccidiosis in birds, and (5) purifying bacitracin or a bacitracin-metal salt.

Bacitracin-metal-polyether antibiotic complexes

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating ingestations of the pinworms Syphacia obcelata and Aspicularis tetraptera in mammals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

Manganese complexes of various monovalent and divalent polyether antibiotics are provided which act as coccidiostats and growth promoting agents when administered to food-producing animals such as cattle, sheep, swine and poultry. Soluble manganese salt is added to a fermentation beer containing the polyether antibiotics to form an insoluble, recoverable biomass containing the desired manganese antibiotic complex. This biomass, in a dried form, can be given orally to animals such as cattle, sheep, swine and poultry. The subject manganese complexes include: linear monovalent and divalent polyethers (monensin, nigericin, lasalocid, lysocellin, etc.); non-glycolic monovalent monoglycoside polyethers (septamycin, dianemycin, lenoremycin, carriomycin and antibiotic A-204); mononitrogen-containing divalent pyrrole ethers (calcimycin, X-14547, etc.); polynitrogen-containing divalent pyrrole ethers (A-23187, etc.); glycolic monovalent monoglycoside polyethers (etheromycin, etc.); other polyether antibiotics including ionomycin, aabomycin, disnerycin, duamycin, BL-580, K-41, SF-1195, M-4164A, A-32887, 30,504RP, 38,986, 44,161, 47,433, 47,434 and 47,224. The above manganese complexes are also active agents for improving cardiovascular function in animals. Purified manganese-containing antibiotic complexes can be extracted from the biomass using suitable organic solvents, followed by crystallization or precipitation of the purified complexes. The purified products can be administered as boluses, subcutaneous implants, or as injectable preparations.

Manganese-containing antibiotic agents

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating infestations of the pinworms Syphacia obvelata and Aspicularis tetraptera in mannals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

Control of parasitic worm (helminth) infestations in warm-blooded animals including poultry, swine, cattle, sheep and goats by administering substituted quinoxaline adducts to infested animals. In particular, certain adducts of quinoxaline-1,4-dioxides are capable of eliminating infestations of the pinworms Syphacia obvelata and Aspicularis tetraptera in mammals. Several of the compounds are also effective against the tapeworm Hymenolepsis nana in mammals.

Nitrohydroxyalkylquinoxaline-1,4-dioxides represented by the formula ##STR1## where R is hydrogen, lower alkyl of 1-3 carbon atoms, hydroxymethyl or acetoxymethyl and R' is hydrogen or lower alkyl of 1-2 carbon atoms or R and R' taken together can be alkylene of 5 carbon atoms and alkanoic acid esters thereof. The compounds are useful for promoting growth rate of animals and improving their feed efficiency.

Nitrohydroxyalkyl-substituted quinoxaxiline dioxides and alkanoic acid

A composition represented by the formula ##STR1## where R and R.sup.1 can be hydrogen, methyl, ethyl or hydroxymethyl and can be the same or different. The compounds are useful for promoting the growth of animals.

Oxazolidinyl-quinoxalines and use as growth promoters

Nitro-olefin-substituted quinoxaline dioxides represented by the formula: ##STR1## where R is hydrogen or methyl. The compounds are useful for controlling the growth of bacteria and fungi.

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Terre Haute, IN, United States of America

Vernon V Young