Medtronic, Inc.

Verhoeven Michel

Patrick T Cahalan

Marc Hendriks

Linda L Cahalan

Mark W Torrianni

Benedicte Fouache

Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups to form activated carboxyl groups, and contacting the activated collagen carboxyl groups with a polyfunctional spacer to crosslink the collagen-based material.

Growing community of inventors

Maastricht, Netherlands

Verhoeven Michel