Centre National De La Recherche Scientifique

Graftys

University De Nantes

Université De Nantes

Graftys Sa

Verena Schnitzler

Bruno Bujoli

Jean-Michel Bouler

Pascal Janvier

Ibrahim Khairoun

Charlotte Mellier

The present invention relates to a gallium-doped phosphocalcic compound of formula (I):CaGa(PO)&#x2003;&#x2003;(I) The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).

Gallium-doped phosphocalcic compounds

The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I):CaGa(PO)&#x2003;&#x2003;(I)wherein 0&#x3c;x&#x3c;1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.

Galliated calcium phosphate biomaterials

Growing community of inventors

Nantes, France

Verena Schnitzler