Helmholtz-zentrum Fuer Infektionsforschung Gmbh

Helmholtz-zentrum Fur Infektionsforschung Gmbh

Universitätsmedizin Der Johannes Gutenberg-universitat Mainz

Verena Fetz

Roland Stauber

Mark Broenstrup

Werner Tegge

Stephan Hüttel

Mark Brönstrup

Stephan Huettel

Haiyu Hu

Galina Sergeev

Wera Collisi

Bushra Rais

Katrin I Mohr

Kevin Ferreira

Philipp Klahn

Shirley K Knauer

Wolf Mann

The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.

Targeted cytotoxic ratjadone derivatives and conjugates thereof

The present invention relates to new compounds comprising a siderophore moiety as well as a core structure able to chelate a metal ion. Optionally, the compounds may have additionally a moiety with a functional element including a marker molecule, a bioactive agent, an activity based probe suitable to monitor the aberrant expression or activity of proteins involved in the initiation and progression of bacterial infection, or a compound useful for bacterial inhibition. In a further aspect, the present invention provides a pharmaceutical composition containing said compound, for example, said pharmaceutical composition is an antibiotic. Additionally, the present invention relates to the use of said compounds in diagnostic methods, in particular, imaging methods including SPEC, PET or MRI. In an embodiment of the present invention, the compound is part of a theranostic composition having both, therapeutic as well as diagnostic activities.

1,4,7,10-tetrazacyclododecane based agents to target bacteria and its use

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Berlin, Germany

Verena Fetz