Ge Healthcare As

Amersham Health As

Vera Kasparkova

Anne Kjersti Fahlvik

Ingrid Henriksen

Arnfinn Andersen

Tore Omtveit

Liv Ingrid Odegardstuen

Method and apparatus for continuous infusion to a subject of dispersions in which the dispersed phase is susceptible to flotation or sedimentation. The dispersion is controllably delivered from an upper or lower extremity of an essentially vertically positioned delivery vessel, e.g. syringe, and is then admixed with flushing medium, e.g. from infusion minibag, prior to administration to the subject. Vertical positioning of the delivery device maximises the distance through which flotation or sedimentation may occur, thereby substantially reducing the effects of separation over a given period of time compared to use of a corresponding horizontal delivery vessel such as a syringe placed in a conventional syringe driver.

Administering a gravity segregation dispersion by continuous infusion

The invention provides a process for the preparation of a pharmaceutical composition comprising an aqueous dispersion of gas-containing vesicles the membranes whereof comprise an amphiphilic membrane-forming material, said process comprising: (i) generating a liquid dispersion of gas-containing vesicles from a mixture comprising an amphiphilic membrane forming material; (ii) lyophilizing a liquid dispersion of said gas-containing vesicles; (iii) reconstituting the lyophilized product of step (ii) with a sterile aqueous liquid to produce an aqueous dispersion of gas-containing vesicles; and (iv) treating the aqueous dispersion product of step (iii) or the lyophilized product of step (ii) to produce a substantially aggregate-free sterile aqueous dispersion of gas-containing vesicles.

Process for preparing contrast agents

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Oslo, Norway

Vera Kasparkova