Sanofi

Lead Pharma Holding B.v.

Lead Pharma B.v.

Vera De Kimpe

Joseph Maria Gerardus Barbara Cals

Sander Bernardus Nabuurs

Jaap Gerardus Henricus Lemmers

Cosimo Damiano Cadicamo

The present invention relates to compounds according to Formula I: or a pharmaceutically acceptable salt thereof. The compounds can be used as inhibitors of RORy and are useful for the treatment of RORy mediated diseases such as autoimmune and inflammatory diseases. 

ROR gamma (RORy) modulators

Compounds according to Formula I: or a pharmaceutically acceptable salt wherein: Ais NRor CR, with Rherein; the cyclopropyl moiety with one or more methyl and one or more F; A-Aare N or CR-CR, with no more than two of the four positions A in A-Acan be simultaneously N; R-Rare described; Rand Rare independently H, F, methyl, ethyl, hydroxyl or methoxy or Rand Rtogether is carbonyl, all alkyl groups, if substituted with one or more F; Ris H or C(1-6)alkyl; A-Aare N or CR-CR, with no more than two of the four positions A in A-Acan be simultaneously N; R-Rherein; Rand Rherein; or Rand Rfused forming a ring having 5 to 7 atoms by joining Rbeing C(1-6)alkyl or C(2-6)alkenyl. The ROR&#x3b3; compounds can treat ROR&#x3b3; mediated diseases.

ROR gamma (ROR&#x3b3;) modulators

Compounds according to Formula I: or a pharmaceutically acceptable salt thereof wherein: Ais NRor CR, with Rbeing H or methyl, with methyl, if present, optionally being substituted with one or more F; the cyclopropyl moiety can be optionally substituted with one or more methyl and one or more F; A-Aare N or CR-CR, respectively, with the proviso that no more than two of the four positions A in A-Acan be simultaneously N; R-Rare independently H, halogen, amino, C(1-3)alkoxy, (di)C(1-3)alkylamino or C(1-6)alkyl; Rand Rare independently H, F, methyl, ethyl, hydroxyl or methoxy or Rand Rtogether is carbonyl, all alkyl groups, if present, optionally being substituted with one or more F; Ris H or C(1-6)alkyl; Ris selected from the group consisting of Formula II, III, IV and V  The compounds can be used as inhibitors of ROR&#x3b3; and are useful for the treatment of ROR&#x3b3; mediated diseases.

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Oss, Netherlands

Vera De Kimpe