Asana Biosciences, LLC

Mersana Therapeutics, Inc.

Mersana Therpeutics, Inc.

Venu Reddy Gurijala

Timothy B Lowinger

Aleksandr V Yurkovetskiy

Mao Yin

Cheri A Stevenson

Joshua D Thomas

Roger Astbury Smith

Nitin Krishnaji Damle

Dennis McGillicuddy

Satyanarayan Reddy Bollu

Jacques Leblanc

A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

Protein-polymer-drug conjugates

The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.

Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates

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Lancaster, MA, United States of America

Venu Reddy Gurijala