Willow Laboratories, Inc.

Cercacor Laboratories, Inc.

Venkatramanan Krishnamani

Kevin Hughes Pauley

Hung The Vo

Massi Joe E Kiani

Cristiano Dalvi

Jeroen Poeze

Jesse Chen

Ruiqi Long

Mohamed Kheir Diab

Ferdyan Lesmana

Gregory A Olsen

Frank Lee

Sai Kong Frank Lee

Anando Devadoss

Derek Treese

Sergei Petrovich Balashov

Sahand Pirbadian

Embodiments of the present disclosure provide insulin formulations having a near neutral pH and improved pharmacokinetic/pharmacodynamic properties, and uses in insulin infusion devices that may provide extended infusion period up to 7-14 days. Also provided are systems for administering insulin, the system may include a first reservoir, a second reservoir, an insulin pump configured to administer contents of the first reservoir or the second reservoir, and one or more hardware processors in communication with the insulin pump.

Insulin formulations and uses in infusion devices

A system which provides closed loop insulin administration is disclosed. The system includes redundant glucose sensors which may be interleaved in order to provide monitoring when one of the glucose sensors is in a settling period. The system may include a disease management unit which includes both a glucose sensor and an insulin pump. A closed loop disease management system which bases insulin administration on accurate glucose measurements may improve a patient's quality of life.

Method of operating redundant staggered disease management systems

Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.

Indicator compounds, devices comprising indicator compounds, and methods of making and using the same

Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

Non-invasive medical monitoring device for blood analyte measurements

Growing community of inventors

Irvine, CA, United States of America

Venkatramanan Krishnamani