Eli Lilly and Company

Other

Johns Hopkins University

Baylor College of Medicine

Venkatesh Krishnan

Ming-Jer Tsai

Sophia Yang Tsai

Philip Arden Beachy

Prabhakar Kondaji Jadhav

Chien-Huan Chen

Jeffrey A Dodge

Charles Willis Lugar, Iii

Blake L Neubauer

Donald Paul Matthews

Bryan Hurst Norman

Gregory Alan Stephenson

Timothy Ivo Richardson

Lance Allen Pfeifer

Jonathan Edward Green

Ashraf Saeed

Euibong Jemes Kim

Phillip A Beachy

Chen-Huan Chen

The present invention provides novel selective androgen receptor modulators and their salts and pharmaceutical compositions thereof. 

4-aminobenzonitrile selective androgen receptor modulators

The present invention provides a compound of the Formula (I), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating or preventing physiological disorders, particularly reduced bone mass, osteoporosis, osteopenia, reduced muscle mass or strength, or erectile dysfunction comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. 

Tetrahydrocyclopenta[b]indole androgen receptor modulators

The present invention relates to the compound of the formula: to pharmaceutical compositions comprising the compound of Formula (I); and to methods for treating or preventing hypogonadism, osteoporosis, osteopenia, sarcopenia, cachexia, muscle atrophy, sexual dysfunction or erectile dysfunction, comprising administering to a patient in need thereof an effective amount of the compound of Formula (I).

Androgen receptor modulator and uses thereof

The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.

Modulation of hedgehog-mediated signaling pathway

The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the present invention are useful as Estrogen Receptor &#x3b2; agonists. Such agonists are useful for the treating Estrogen Receptor &#x3b2; mediated diseases such as prostate cancer.

Substituted benzopyrans as selective estrogen receptor-beta agonists

Method for identifying an agent that affects a hedgehog signaling pathway

The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the present invention are useful as Estrogen Receptor &bgr; agonists. Such agonists are useful for treating Estrogen Receptor &bgr; mediated diseases such as prostate cancer.

Substituted benzopyrans as selective estrogen receptor &bgr; agonists

Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor

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Fishers, IN, United States of America

Venkatesh Krishnan