Phyton Holdings, LLC

Phyton Corporation

Phyton Catalytic, Inc.

Venkataraman Bringi

Prakash G Kadkade

Braden Roach

Christopher Prince

Christopher Lucas Prince

Barry F Schubmehl

Eugene J Kane

Christopher L Prince

This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all knownspecies, e.g.,and. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture ofis particularly enhanced by use of one or more of these conditions, yield of taxanes for allspecies has been found to benefit from use of these conditions.

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This invention is directed to methods for the enhanced production and recovery of taxol and taxanes by cell cultures of Taxus species.

Enhanced production of taxol and taxanes by cell cultures of taxus

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Ithaca, NY, United States of America

Venkataraman Bringi