Nereus Pharmaceuticals, Inc.

Sirenas LLC

Venkata Rami Reddy Macherla

Barbara Christine Potts

Kin S Lam

Rama Manam

Benjamin Nicholson

Katherine A McArthur

Taotao Ling

Michael A Palladino

Steven Bruce Cohen

Saskia Theodora Cornelia Neuteboom

Ippei Usui

Alexander Wayne Schammel

Jacob Neal Beverage

Bryan Junn Lee

Eduardo Esquenazi

Elizabeth Paige Stout

Oliver Booth Vining

Kin Sing Lam

Rama Rao Manam

Katherine Mcarthur

Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

Anti-cancer compounds and conjugates thereof

The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V). 

Total synthesis of salinosporamide A and analogs thereof

Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.

Anti-cancer and anti-microbial oxazolidinones

Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.

Methods of using [3.2.0] heterocyclic compounds and analogs thereof

Disclosed herein are novel pyrroloterpene compounds and methods for obtaining these compounds. Also disclosed are methods of treating cancer and bacterial infections using the novel pyrroloterpene compounds.

Pyrroloterpenes and use of the same as antimicrobial and anticancer agents

Anti-cancer and anti-microbial 5-membered heterocyclic compounds

Growing community of inventors

San Diego, CA, United States of America

Venkata Rami Reddy Macherla