Novartis Ag

Alcon, Inc.

Venkat Shankar

Frank Chang

Jinyu Huang

Xinming Qian

Robert A Scott

Yongxing Qiu

Troy Vernon Holland

Yasuo Matsuzawa

John Dallas Pruitt

Arturo Norberto Medina

Chung-Yuan Chiang

Dawn Alison Smith

Selma Kuyu

Yash Kapoor

Daqing Wu

The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

Azetidinium-containing copolymers and uses thereof

The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.

Soft silicone medical devices with durable lubricious coatings thereon

The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C-Calcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.

Method for determining the surface concentration of carboxyl groups on a lens

The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

Water-processable silicone-containing prepolymers and uses thereof

The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.

Method for producing contact lenses with durable lubricious coatings thereon

The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.

Polymerizable polysiloxanes with hydrophilic substituents

The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention.

Actinically-crosslinkable amphiphilic prepolymers

The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

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Suwanee, GA, United States of America

Venkat Shankar