Howmedica Osteonics Corporation

Orthovita, Inc.

Takeda Pharmaceutical Company Limited

Venkat R Garigapati

Brian J Hess

Matthew E Murphy

Adrian Sun Wai

Donal O'Mahony

Jon Ahola

Tetsuya Matsuura

Cassandra L Kimsey

Kevor S TenHuisen

Anthony Patrick Napolitano

Renwen Zhang

Twana Davisson

Jeffrey Spalazzi

Donal O'mahony

The invention provides, inter cilia, ultra-thin conformal coated biological surfaces, such as living cells, cell clusters, tissues, organs, and hybrid synthetic organs, and methods of making the same, e.g., using click reactive water soluble polymers, under conditions that do not damage or significantly modify the biological surfaces. In some embodiments, the coated biological surfaces are suitable for delivery to a subject in need thereof.

Conformal coating of biological surfaces

The invention provides, inter alia, ultra-thin conformal coated biological surfaces, such as living cells, cell clusters, tissues, organs, and hybrid synthetic organs, and methods of making the same, e.g., using click reactive water soluble polymers, under conditions that do not damage or significantly modify the biological surfaces. In some embodiments, the coated biological surfaces are suitable for delivery to a subject in need thereof.

Certain small molecule amino acid phosphate compounds such as phosphoserine and certain multivalent metal compounds such as calcium phosphate containing cements have been found to have improved properties and form an interpenetrating network in the presence of a polymer that contains either an electronegative carbonyl oxygen atom of the ester group or an electronegative nitrogen atom of the amine group as the bonding sites of the polymer surfaces to the available multivalent metal ions.

Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods

Compositions comprising thrombin and collagen and methods of preparation thereof are disclosed herein. In one embodiment, a composition comprises thrombin and collagen in an aqueous buffer solution, wherein the buffer solution includes at least one of a first compound represented by Formula I: R&#x2014;C(O)&#x2014;OM, wherein Ris &#x2014;CH, &#x2014;CHCHC(O)OH, or &#x2014;CHCHC(O)OM, and wherein Mis a monovalent ion; or a second compound represented by Formula II: R&#x2014;C(O)&#x2014;OMO&#x2014;C(O)&#x2014;R, wherein Ris &#x2014;CHor &#x2014;CHCH, and wherein Mis a divalent ion. In one embodiment, the buffer solution includes sodium acetate, calcium propionate, and sorbitol.

Stable compositions containing thrombin and methods for preparation and use thereof

Disclosed are pepsinized collagen implants, such as membranes and sponges, and methods of making them, which entails solubilizing pepsinized collagen in a buffer containing a polyol, e.g., mannitol or sorbitol, wherein the buffer has a substantially neutral pH. Methods of using the pepsinized collagen implants for clinical applications are also disclosed.

Pepsinized collagen implants and biomedical uses thereof

A non-invasive device for anchoring a suture includes a sheet to which a suture can be attached and an adhesive that can affix the sheet to bone. The method provides placing effective amount of an adhesive on a bone and attaching the suture to the adhesive and allowing the adhesive to set.

Non-invasive suture anchor and method

Certain small molecule amino acid phosphate compounds such as phosphoserine and certain multivalent metal compounds such as calcium phosphate containing cements have been found to have improved properties and form an interpenetrating network in the presence of a polymer that contain either an electronegative carbonyl oxygen atom of the ester group or an electronegative nitrogen atom of the amine group as the bonding sites of the polymer surfaces to the available multivalent metal ions.

Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least multivalent metal compound, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments which exhibit bond strength upon curing with the possible usage as bone cement for bone filler applications.

Organophosphorous and multivalent metal compound compositions and methods

The present invention relates to a bone cement precursor system that is presented in the form of two shelf-stable pastes which have been terminally sterilized and are held in separate containers during product transport and storage. When the product is used during surgery, these pastes inject to a site of application through a static mixing device by the action of applied injection force. When the two pastes are mixed, they start to react to each other while injecting out. The resulting composition is highly biocompatible, osteoconductive, injectable, rapid setting and bioresorbable, and is useful in connection with bone repair procedures, for example, in the craniomaxillofacial, trauma and orthopedic areas.

Post irradiation shelf-stable dual paste direct injectable bone cement precursor systems and methods of making same

Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least tetra calcium phosphate, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments and exhibit significant bond strength upon curing.

Growing community of inventors

Southborough, MA, United States of America

Venkat R Garigapati