Innovative Pharmacology Research Ooo (iphar)

Obshestvo S Ogranichennoi Otvetsvennostju “leofors”

Obschestvo S Ogranichennoi Otvetstvennoctiyu “macferon”

Obshestvo S Ogranichennoi Otvetstvennostju "innovative Pharmacology Research" ("iphar")

Veniamin Abramovich Khazanov

Nariman Faridovich Salakhutdinov

Tatiana Genrihovna Tolstikova

Konstantin Petrovich Volcho

Alla Viktorovna Pavlova

Oksana Stanislavovna Mikhal'Chenko

Dina Vladimirovna Korchagina

Alexandra Leonidovna Zakharenko

Olga Ivanovna Lavrik

Ekaterina Vladimirovna Khaid

Maksim Lvovich Beljanin

Evgeniy Danilovich Goldberg

Olga Anatolyevna Luzina

Dmitry Nikolaevich Sokolov

Viktor Dmitrievich Filimonov

Alexandr Michailovich Dygai

The present invention relates to the field of molecular biology, biochemistry and biotechnology, namely, to compound 2-acetyl-6-(2-(2-(4-bromobenzylidene)hydrazinyl) thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bh)-one, which is a hydrazine-thiazole derivative of usnic acid of formula I and which is able to inhibit the action of human tyrosyl-DNA-phosphodiesterase 1 enzyme. Technical result: increase in inhibitory action towards human tyrosyl-DNA-phosphodiesterase 1 enzyme (Tdp1) and increase in the number of inhibitors of this enzyme. 1 independent claim, 2 figures, 3 examples.

2-acetyl-6-(2-(2-(4-bromobenzylidene)hydrazinyl)thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[,b,d]furan-1(9bh)-one exhibiting an inhibitory effect on human tyrosyl-DNA-phosphodiesterase 1 enzyme

The invention relates to the use of the compound of general formula 1 or its spatial isomers as an analgesic drug. The compounds have high activity, low toxicity, may be used in medicine.

2H-chromene derivatives as analgesic agents

A method of obtaining D-glucuronic acid. The D-glucuronic acid and its derivatives (lactone, salts, amides, etc.) are biologically high-active compounds, which are widely used in medicine and pharmaceutical chemistry for the synthesis of modified drugs as well as used as food additives, skin-care preparations, and the like. This invention provides an environmentally friendly method of obtaining D-glucuronic acid which has widespread operational possibilities. The D-glucuronic acid is obtained by heating the salts of 1,2-0-isopropylidene-D-glucuronic acid in a water-containing solution in the presence of an acid agent, for which sulphonic acid cation exchanger resins are used.

Method of obtaining D-glucuronic acid

Growing community of inventors

Tomsk, Russia

Veniamin Abramovich Khazanov