Oy Juvantia Pharma Ltd.

Veli-Pekka Valkonen

Jukka T Salonen

Ullamari Pesonen

Matti Karvonen

Markku Koulu

Mika Scheinin

Tomi-Pekka Tuomainen

Amir Snapir

Kristiina Nyyss&ouml;nen

Timo A Lakka

Riitta Salonen

Pia Alhopuro

Jussi Kauhanen

Paula Heinonen

This invention relates to a DNA sequence comprising a nucleotide sequence encoding a variant &agr; -adrenoceptor protein and to the variant &agr; -adrenoceptor protein as well as a method for screening a subject to determine if the subject is a carrier of a variant gene that encodes the variant &agr; -adrenoceptor protein. Further this invention relates to a method for treating a mammal suffering from vascular contraction of coronary arteries, the method comprising the step of administering a selective &agr; -adrenoceptor antagonist to the mammal and to transgenic animals comprising a human DNA molecule encoding human &agr; -adrenoceptor protein or the variant &agr; -adrenoceptor protein.

DNA molecule encoding a variant &agr;2B-adrenoceptor protein, and uses thereof

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Kuopio, Finland

Veli-Pekka Valkonen