Fresenius Ag

Fresenius Hemocare Gmbh

Fresenius Medical Care Deutschland Gmbh

Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh

Helmholtz-Zentrum Geesthacht Zentrum Fur Material Und Kustenforschung Gmbh

Veit Otto

Hans-Peter Leinenbach

Martin Hepper

Wolfgang Metzger

Wolfram Weber

Michael Hoffmann

Roland Horres

Franz-Josef Gerner

Dagmar Boltersdorf

Michael Zimmermann

Andreas Kokott

Ali Abdullah Tareq Hasson

Iris Muller-Stein

Wolfgang Schiebler

Stefan Schulze

Heike Mitschulat

Martin Schimmel

Walter Ruger

Gunter Mathar

Hanno Baumann

The invention provides a process by which tubular tissue supports (stents) can be removed from hollow organs of humans or of animals after heating to a temperature below the transition temperature Ttrans until softening occurs.

Removal of tubular tissue supports

An adsorbent for whole blood in the form of essentially spherical non-aggregated particles. The adsorbent comprises a porous carrier material having an average pore size of &#x2266;1.5 &#x3bc;m, whereby a maximum of 50% of the pore volume may be in pores having a pore size of &#x3e;1.5 &#x3bc;m, whereby the outer surfaces of the porous carrier material have at least one surface modification Mso that the outer surface essentially does not interact with blood cells, and the inner surfaces of the porous carrier material, e.g., the surfaces of the pores of the porous carrier material, have at least one surface modification Mwhich interacts with substances present in blood.

Adsorbent having differently modified surface areas, method for the production thereof and use of the same

A process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma in which a carrier material, which is preferably a copolymer derived from (meth)acrylates and or (meth)acrylic acid amides, is activated by amination, and subsequently undergoes thermal treatment at a temperature of over 100&deg; C. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin, an adsorbent and method of producing an adsorber from the adsorbent

An adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma comprises a matrix and synthetic lateral chains that are covalently bonded to the matrix. The lateral synthetic chains are comprised of at least two amino groups in which the N atoms are at least 2.6 &angst; apart within at least one lateral synthetic chain. The matrix exhibits porous, unaggregated, spherical particles in a range of particle sizes from 50 to 250 &mgr;m, which possess an exclusionary threshold of at least 10 Daltons, and they exhibit no peptides or aromatic groups of any kind. The at least two amino groups are preferably separated from one another by 4 to 6 carbon atoms. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Adsorbent for reducing the concentration of fibrinogen and/or fibrin, method of producing an adsorber from the adsorbent, and an adsorber with the adsorbent

The invention relates to a device for purifying protein-containing solutions such as blood, blood plasma or cell culture media, where a biocompatible support material made of a plastic material, selected from the group of polyacrylates, polymethacrylates, polysulfone and polyether sulfone, is coated with albumin, which is bound by peptide binding. In addition, the invention relates to a method of producing the support material according to this invention and the use of the device.

Device for purifying solutions containing proteins and use of the device

A material for the elimination of biomacromolecules, in particular LDL and endotoxins from a whole blood circuit, comprising an adsorbent, comprising a porous carrier material of a homo-, co-, or terpolymer of acrylic acid and/or methacrylic acid with a particle range of between 50 and 250 .mu.m, an exclusion level of at least 5.times.10.sup.5 daltons, as well as organic ligands which are covalently bound to the carrier material via a spacer, wherein the carrier material has a spherical shape and suitably, the spacer contains no double bonds.

Particulate adsorbent for the removal of biomacromolecules such as LDL

An improved apparatus (10) is made available for separating at least two biological substances in solution by adsorption and comprises in the upper interior section (28) of its housing (10) a means effecting a partial constriction of the cross-section of said interior section (28), said section thereby being divided into an upper and lower subspace (34; 36), and which is further distinguished in that the upper subspace (34) and the lower subspace (36) are in flow connection with each other both as regards the solution to be separated and the adsorption agent particles, the feed tube (40) for the solution to be separated being arranged in such a manner that the discharge of the solution to be separated takes place in the lower subspace (36), and the apparatus is a self-contained in unit in sterile form.

Apparatus for separating at least two biological substances in solution

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St. Wendel, Germany

Veit Otto