Topivert Pharma Limited

Respivert Limited

Vedran Hasimbegovic

Stephen Thom

Matthew Colin Thor Fyfe

Thomas Matthew Baker

Gareth Harbottle

Aaron Rigby

Premji Meghani

Colin Peter Sambrook-Smith

Gareth William Harbottle

There are provided compounds of formula I, wherein Rto R, Rto R, L and Xto Xhave meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

Kinase inhibitors

There are provided compounds of formula I, wherein R, R, Rto R, R, R, X, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

Urea derivatives useful as kinase inhibitors

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Nottingham, United Kingdom

Vedran Hasimbegovic