Third Wave Technologies, Inc.

Luminex Corporation

Vecheslav A Elagin

Scott M Law

Marilyn C Olson-Munoz

Sarah Olson

Tamara J Sander

Hon Ip

Michelle Curtis

Robert W Kwiatkowski

Poonam Agarwal

Angela Hudson

Ilse Tyler

Michelle Garsha

Hatim T Allawi

Victor I Lyamichev

LuAnne Chehak

Kwok Wu

Walter Iszczyszyn

Chris Fleming

Bjork Hill

Michael James Moser

Disclosed are methods, kits, and components for detecting small RNA molecules, such as microRNA and siRNA, in a sample. The methods utilize primers and reporter molecules comprising non-natural bases. The disclosed kits may include one or more components for performing the disclosed methods.

Methods for detection and quantification of small RNA

The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.

Detection of HPV

The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure invasive cleavage assays, as well as T-structure related target dependent non-target amplification methods and compositions. The present invention further relates to methods, compositions, devices and systems for consistent nucleic acid dispensing onto surfaces.

T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection

The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, to determine HCV genotype.

Determination of hepatitis C virus genotype

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Waunakee, WI, United States of America

Vecheslav A Elagin