Council of Scientific and Industrial Research

Vasudevan Natarajan

Dumbala Srinivasa Reddy

Amol Arvind Kulkarni

Kashinath Komirishetty

Gorakhnath Rajaram Jachak

Mrityunjay Keshavprasad Sharma

The present disclosed an improved process for the synthesis of ivacaftor starting from indole acetic acid ester which can be performed in batch as well as continuous flow synthesis. The present invention further disclosed to a continuous process for the synthesis of compound of formula (II) or formula (III) from compound of formula (I) in continuous flow reactor.

Process for the synthesis of ivacaftor

The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R, R, R, R, R, R, Rand Arare as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides. 

Process for the synthesis of ivacaftor and related compounds

Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

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Vasudevan Natarajan