The Austin Research Institute

The Macfarlane Burnet Institute for Medical Research and Public Health Limited

Vianex S.a.

Vasso Apostolopoulos

Geoffrey Alan Pietersz

Ian F C McKenzie

Geoff Allan Pietersz

Ian F McKenzie

Mauro Sergio Sandrin

Lesley Probert

John Matsoukas

Theodoros Tselios

Vivian Tseveleki

Ian Farquar Campbell McKenzie

Maria Katsara

Geoff Allen Pietersz

George Deraos

Athanasios Lourbopoulos

Ian Farquar Mckenzie

Theodore Tselios

Nikos Grigoriadis

A first aspect of the invention relates to a conjugate including mannan and at least one epitope comprising a peptide fragment of a protein selected from myelin basic protein (MBP), myelin oligodentrocyte glycoprotein (MOG) and proteolipid protein (PLP), said peptide fragment being in linear or cyclic form; and wherein said epitope is linked to mannan via a [(Lys-Gly)] bridge, where n is an integer from 1 to 10. Further aspects of the invention relate to pharmaceutical compositions comprising said conjugates, and their use in the preparation of a medicament for treating an immune disorder.

Conjugates comprising mannan and myelin oligodentrocyte glycoprotein (MOG)

The present invention relates to a method of eliciting a cytotoxic T lymphocyte response to an antigen in an animal, the method comprising pulsing mannose receptor-bearing antigen presenting cells in vitro or ex vivo with a conjugate comprising an antigen and a carbohydrate polymer comprising mannose, wherein said carbohydrate polymer is a fully oxidized carbohydrate polymer comprising free aldehydes; and administering the pulsed antigen presenting cells to an animal.

Compositions for immunotherapy and uses thereof

The present invention relates to an immunogenic composition comprising a conjugate between an antigen and an oxidized mannan comprising mannose units and aldehyde groups, and a pharmaceutically acceptable carrier.

Conjugates between whole antigen or one or more repeated subunits of an antigen and a carbohydrate polymer are described. Also described are immunogenic vaccines against disease states which contain the conjugates and methods for inducing cell-mediated immune responses. The conjugates may especially contain polymers of the carbohydrate mannose and one or more repeated subunits of human mucin or non-repeated regions of human mucin.

Antigen carbohydrate compounds and their use in immunotherapy

Peptide mimicks of MUC1 or other cancer peptides which can be included in cancer vaccines and used in therapeutic methods for the treatment of cancer patients.

Mimicking peptides in cancer therapy

Conjugates between one or more repeated subunits of an antigen and a carbohydrate polymer are desired. Also described are immunogenic vaccines against disease states which contain the conjugates and methods for inducing cell-mediated immune responses. The conjugates may especially contain polymers of the carbohydrate mannose and one or more repeated subunits of human mucin.

Growing community of inventors

St. Albans, Australia

Vasso Apostolopoulos