The University of Manchester

Vassilis Gorgoulis

Nikolaos Lougiakis

Nicole Pouli

Panayiotis Marakos

Nikolaos Kastrinakis

Paul Townsend

The present disclosure relates to compounds of the formula (1) that function as senescent cell detectors: wherein the SBB analogues refer to de novo synthesized derivatives with structural similarity to the Sudan Black B dye, L is an appropriate chemical bond and hapten is biotin, or digoxigenin, or 2,4-dinitrophenol, or fluorescein, but more preferably biotin. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. 

Compounds, linked with haptens, for the detection of senescent cells

The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R, R, R, Rand Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB). 

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Athens, Greece

Vassilis Gorgoulis