Pennwalt Corporation

Usv Pharmaceutical Corporation

Vassil St Georgiev

Bernard Loev

George B Mullen

Richard E Brown

Philip Kropp

John T Suh

Bruce E Williams

C Richard Kinsolving

.alpha.-Substituted ketonitrone derivatives containing substitutents selected from hydrogen, phenyl, substituted phenyl, naphythyl, furan, thiopen, imidazolylmethyl and triazolylmethyl are useful as intermediates for the preparation of biologically active isoxazolidine compounds.

Alpha-substituted ketonitrone derivatives

3-(Substituting phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]m ethyl}isoxazolidines in which hydrogens of their phenyl rings may be replaced by halogen, lower alkoxy, lower alkyl or nitro groups, and the sulfur atom may be oxidized, are useful as antifungal agents.

3-(Substituted

3-(substituted phenyl)-3-(1H-1,2,4-triazol-1-yl)methyl-2-methyl-5-[(substituted phenoxy)methyl]isoxazolidine derivatives in which hydrogens of their phenyl rings may be replaced by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, alkanoylamino or nitro groups are useful as antifungal agents.

Substituted 5-(phenoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine s, in which hydrogens of their benzene rings may be replaced by halogen, lower alkoxy, lower alkyl, nitro, acetamido and/or trifluoromethyl groups, are useful as antifungal agents.

Substituted

Substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines in which hydrogens of their phenyl rings may be replaced by halogen, lower alkoxy or lower alkyl groups are useful as antifungal agents.

New triazoloquinoxalin-1,4-diones are described as well as the use thereof as anti-allergenic agents.

Triazoloquinoxalin-1,4-diones

Pyridotriazolopyrazine-diones for treating allergy

Esters of 2-adamantanone oxime are prepared and are disclosed as possessing anti-inflammatory activity and antiviral activity against murine hepatitis virus.

Esters of 2-adamantanone oxime

Provided is a method of treating asthma. The method is the administering to a patient requiring treatment of an effective dose of a benzoxazole-2-carboxylic acid or an ester or therapeutically-acceptable salt of benzoxazole-2-carboxylic acid.

Method of treatment of asthma

Thiazoloquinoxalin-1,4-diones for treating allergy

New substituted triazoloquinoxalin-4-ones are described as well as the use thereof as anti-hypertensive agents.

Growing community of inventors

Rochester, NY, United States of America

Vassil St Georgiev